Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?

Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?

Upon recognition of microbial DNA or self-DNA, the cyclic-GMP-AMP synthase (cGAS) of the host catalyzes the production of the cyclic dinucleotide cGAMP. cGAMP is the main activator of STING, stimulator of interferon genes, leading to interferon synthesis through the STING-TBK1-IRF3 pathway. STING is...

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Bibliographic Details
Main Authors: Jean-Marie Berthelot, Frédéric Lioté, Yves Maugars, Jean Sibilia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
cGAMP
lymphopenia
interferon
STING
COVID-19
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.607069/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.607069/full

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