LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose

LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose

Abstract Background Understanding the pathophysiology of the blood brain–barrier (BBB) plays a critical role in diagnosis and treatment of disease conditions. Applying a sensitive and specific LC–MS/MS technique for the measurement of BBB integrity with high precision, we have recently introduced no...

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Bibliographic Details
Main Authors: Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Yeseul Ahn, Dhavalkumar Patel, Abraham Al-Ahmad, Reza Mehvar, Ulrich Bickel
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Mannitol
Sucrose
Vascular space correction
Permeability coefficient
Brain uptake clearance
Online Access:http://link.springer.com/article/10.1186/s12987-020-00224-1

Internet

http://link.springer.com/article/10.1186/s12987-020-00224-1

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