Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI.

Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological fMRI.

Nalbuphine, an agonist-antagonist kappa-opioid, produces brief analgesia followed by enhanced pain/hyperalgesia in male postsurgical patients. However, it produces profound analgesia without pain enhancement when co-administration with low dose naloxone. To examine the effect of nalbuphine or nalbup...

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Bibliographic Details
Main Authors: Robert Gear, Lino Becerra, Jaymin Upadhyay, James Bishop, Diana Wallin, Gautam Pendse, Jon Levine, David Borsook
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3540048?pdf=render

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http://europepmc.org/articles/PMC3540048?pdf=render

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