Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins

The ancient paralogs premelanosome protein (<i>PMEL</i>) and glycoprotein nonmetastatic melanoma protein B (<i>GPNMB</i>) have independently emerged as intriguing disease loci in recent years. Both proteins possess common functional domains and variants that cause a shared sp...

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Bibliographic Details
Main Authors: Paul W. Chrystal, Tim Footz, Elizabeth D. Hodges, Justin A. Jensen, Michael A. Walter, W. Ted Allison
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/26/12/3529