Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase

Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase

In this study, a stepwise reaction afforded thiazolidinone-based benzothiazole derivatives <b>1</b>–<b>15</b>, and the synthesized derivatives were then screened for biological significance and found to be the leading candidates against α-amylase and α-glucosidase enzymes. Al...

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Bibliographic Details
Main Authors: Shoaib Khan, Shahid Iqbal, Marwa Khan, Wajid Rehman, Mazloom Shah, Rafaqat Hussain, Liaqat Rasheed, Yousaf Khan, Ayed A. Dera, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
synthesis
α-amylase and α-glucosidase enzymes
thiazolidinone
benzothiazole
SAR
molecular docking
Online Access:https://www.mdpi.com/1424-8247/15/10/1164

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https://www.mdpi.com/1424-8247/15/10/1164

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