Passive Transfer of Sera from ALS Patients with Identified Mutations Evokes an Increased Synaptic Vesicle Number and Elevation of Calcium Levels in Motor Axon Terminals, Similar to Sera from Sporadic Patients

Passive Transfer of Sera from ALS Patients with Identified Mutations Evokes an Increased Synaptic Vesicle Number and Elevation of Calcium Levels in Motor Axon Terminals, Similar to Sera from Sporadic Patients

Previously, we demonstrated increased calcium levels and synaptic vesicle densities in the motor axon terminals (MATs) of sporadic amyotrophic lateral sclerosis (ALS) patients. Such alterations could be conferred to mice with an intraperitoneal injection of sera from these patients or with purified...

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Bibliographic Details
Main Authors: Valéria Meszlényi, Roland Patai, Tamás F. Polgár, Bernát Nógrádi, Laura Körmöczy, Rebeka Kristóf, Krisztina Spisák, Kornélia Tripolszki, Márta Széll, Izabella Obál, József I. Engelhardt, László Siklós
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
ALS
passive transfer
intracellular calcium
synaptic vesicles
SOD1 mutation
C9ORF72 mutation
Online Access:https://www.mdpi.com/1422-0067/21/15/5566

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https://www.mdpi.com/1422-0067/21/15/5566

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