Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol

Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol

In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human topoisomerase I (TOP1). A total of 13 compounds were synthesized from the natural sesquiterpene (-)-drimen...

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Bibliographic Details
Main Authors: Ileana Araque, Javiera Ramírez, Rut Vergara, Jaime Mella, Pablo Aránguiz, Luis Espinoza, Waleska Vera, Iván Montenegro, Cristian O. Salas, Joan Villena, Mauricio A. Cuellar
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
drimenol
aryl-sesquiterpene esters
cytotoxic activity
caspase
topoisomerase I
docking
Online Access:https://www.mdpi.com/1420-3049/28/9/3959

Internet

https://www.mdpi.com/1420-3049/28/9/3959

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