CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

Naïve T cells establish self-tolerance via negative selection of cells with strong reactivity for self-peptide/MHC complexes, but undergo T-cell receptor (TCR) desensitisation when leaving the thymus. Here, Choet al.show that TCR desensitisation correlates with cell-surface density of the phosphatas...

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Bibliographic Details
Main Authors: Jae-Ho Cho, Hee-Ok Kim, Young-Jun Ju, Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Cheol-Heui Yun, Nunzio Bottini, Kylie Webster, Christopher C. Goodnow, Charles D. Surh, Cecile King, Jonathan Sprent
Format: Article
Language:English
Published: Nature Portfolio 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13373

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https://doi.org/10.1038/ncomms13373

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