Allelic-Specific Regulation of xCT Expression Increases Susceptibility to Tuberculosis by Modulating microRNA-mRNA Interactions

Allelic-Specific Regulation of xCT Expression Increases Susceptibility to Tuberculosis by Modulating microRNA-mRNA Interactions

ABSTRACT xCT forms part of the xc− cysteine-glutamate antiporter which inhibits antimicrobial inflammatory immune functions and thus increases susceptibility to tuberculosis (TB). However, the associations between xCT gene polymorphisms and susceptibility to TB, as well as whether these modulate xCT...

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Bibliographic Details
Main Authors: Wenfei Wang, Yi Cai, Guofang Deng, Qianting Yang, Peijun Tang, Meiying Wu, Ziqi Yu, Fan Yang, Jianyong Chen, Oliver Werz, Xinchun Chen
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mSphere
Subjects:
xCT
polymorphism
tuberculosis
genotype
therapy
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00263-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00263-20

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