Enrichment analysis of phenotypic data for drug repurposing in rare diseases

Enrichment analysis of phenotypic data for drug repurposing in rare diseases

Drug-induced Behavioral Signature Analysis (DBSA), is a machine learning (ML) method for in silico screening of compounds, inspired by analytical methods quantifying gene enrichment in genomic analyses. When applied to behavioral data it can identify drugs that can potentially reverse in vivo behavi...

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Bibliographic Details
Main Authors: Alberto Ambesi-Impiombato, Kimberly Cox, Sylvie Ramboz, Daniela Brunner, Mukesh Bansal, Emer Leahy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
drug discovery
phenotypic screening
tianeptine
huntington (disease)
animal models
smartcube
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1128562/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1128562/full

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