Redirection of Cord Blood T Cells and Natural Killer Cells for Elimination of Autologous HIV-1-Infected Target Cells Using Bispecific DART® Molecules

Redirection of Cord Blood T Cells and Natural Killer Cells for Elimination of Autologous HIV-1-Infected Target Cells Using Bispecific DART® Molecules

Mother-to-child transmission of HIV-1 remains a major global health challenge. Currently, HIV-1-infected infants require strict lifelong adherence to antiretroviral therapy to prevent replication of virus from reservoirs of infected cells, and to halt progression of disease. There is a critical need...

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Bibliographic Details
Main Authors: Justin Pollara, R. Whitney Edwards, Shalini Jha, Chia-Ying Kao Lam, Liqin Liu, Gundo Diedrich, Jeffrey L. Nordstrom, Tori Huffman, Joy A. Pickeral, Thomas N. Denny, Sallie R. Permar, Guido Ferrari
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
pediatric HIV-1
umbilical cord blood
cytotoxic T cells
natural killer cells
redirected cytotoxicity
bispecific DART molecules
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00713/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00713/full

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