The L1 cell adhesion molecule constrains dendritic spine density in pyramidal neurons of the mouse cerebral cortex

The L1 cell adhesion molecule constrains dendritic spine density in pyramidal neurons of the mouse cerebral cortex

A novel function for the L1 cell adhesion molecule, which binds the actin adaptor protein Ankyrin was identified in constraining dendritic spine density on pyramidal neurons in the mouse neocortex. In an L1-null mouse mutant increased spine density was observed on apical but not basal dendrites of p...

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Bibliographic Details
Main Authors: Kelsey E. Murphy, Sarah D. Wade, Justin E. Sperringer, Vishwa Mohan, Bryce W. Duncan, Erin Y. Zhang, Yubin Pak, David Lutz, Melitta Schachner, Patricia F. Maness
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neuroanatomy
Subjects:
L1 cell adhesion molecule
ankyrin
dendritic spines
pyramidal neurons
cortical development
mouse models
Online Access:https://www.frontiersin.org/articles/10.3389/fnana.2023.1111525/full

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https://www.frontiersin.org/articles/10.3389/fnana.2023.1111525/full

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