Glucagon-Like Peptide-2 Stimulates S-Phase Entry of Intestinal Lgr5+ Stem CellsSummary

Glucagon-Like Peptide-2 Stimulates S-Phase Entry of Intestinal Lgr5+ Stem CellsSummary

Background & Aims: Leucine-rich repeat-containing G-protein–coupled receptor-5 (Lgr5)+/olfactomedin-4 (Olfm4)+ intestinal stem cells (ISCs) in the crypt base are crucial for homeostatic maintenance of the epithelium. The gut hormone, glucagon-like peptide-21–33 (GLP-2), stimulates intestinal...

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Bibliographic Details
Main Authors: Maegan E. Chen, Setareh Malekian Naeini, Arjuna Srikrishnaraj, Daniel J. Drucker, Zivit Fesler, Patricia L. Brubaker
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Cell Cycle
GLP-2
Intestine
Lgr5
Olfm4
Proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X22000388

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X22000388

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