Maintenance of active chromatin states by HMGN2 is required for stem cell identity in a pluripotent stem cell model

Maintenance of active chromatin states by HMGN2 is required for stem cell identity in a pluripotent stem cell model

Abstract Background Members of the HMGN protein family modulate chromatin structure and influence epigenetic modifications. HMGN1 and HMGN2 are highly expressed during early development and in the neural stem/progenitor cells of the developing and adult brain. Here, we investigate whether HMGN prote...

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Bibliographic Details
Main Authors: Sylvia Garza-Manero, Abdulmajeed Abdulghani A. Sindi, Gokula Mohan, Ohoud Rehbini, Valentine H. M. Jeantet, Mariarca Bailo, Faeezah Abdul Latif, Maureen P. West, Ross Gurden, Lauren Finlayson, Silvija Svambaryte, Adam G. West, Katherine L. West
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Epigenetics & Chromatin
Subjects:
HMGN
Chromatin
Epigenetics
Stem cells
Embryonal carcinoma cells
Differentiation
Online Access:https://doi.org/10.1186/s13072-019-0320-7

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