Comparative validation of three DNA methylation algorithms of ageing and a frailty index in relation to mortality: results from the ESTHER cohort study

Comparative validation of three DNA methylation algorithms of ageing and a frailty index in relation to mortality: results from the ESTHER cohort study

Background: Three DNA methylation (DNAm) based algorithms, DNAm PhenoAge acceleration (AgeAccelPheno), DNAm GrimAge acceleration (AgeAccelGrim), and mortality risk score (MRscore), based on methylation in 513, 1030, and 10 CpGs, respectively, were established to predict health outcomes and mortality...

Full description

Bibliographic Details
Main Authors: Xiangwei Li, Yan Zhang, Xīn Gào, Bernd Holleczek, Ben Schöttker, Hermann Brenner
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:EBioMedicine
Subjects:
DNA methylation
epigenetic clock
age acceleration
frailty
mortality
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421004801

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421004801

Similar Items