Metabolic Profiling and Investigation of the Modulatory Effect of <i>Fagonia cretica</i> L. Aerial Parts on Hepatic CYP3A4 and UGT2B7 Enzymes in Streptozotocin—Induced Diabetic Model

Metabolic Profiling and Investigation of the Modulatory Effect of <i>Fagonia cretica</i> L. Aerial Parts on Hepatic CYP3A4 and UGT2B7 Enzymes in Streptozotocin—Induced Diabetic Model

Drug-metabolizing enzymes are either boosted or suppressed by diabetes mellitus. This research was designed to explore <i>Fagonia cretica</i> L. aerial parts’ impact on CYP3A4 and UGT2B7 activity and their mRNA expression in diabetic rats. <i>Fagonia cretica</i> (<i>F....

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Bibliographic Details
Main Authors: Shahzad Kamran, Rukhsana Anwar, Afifa Noor, Muhammad Ihsan Ullah, Alaa A. Bagalagel, Mohammed M. Aldurdunji, Saiqa Ishtiaq
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antioxidants
Subjects:
<i>Fagonia cretica</i>
Zygophyllaceae
UGT2B7
CYP3A4
mRNA expression
molecular docking
Online Access:https://www.mdpi.com/2076-3921/12/1/119

Internet

https://www.mdpi.com/2076-3921/12/1/119

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