Promotion of homology-directed DNA repair by polyamines

The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA double-strand break repair through the stimulation o...

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Bibliographic Details
Main Authors: Chih-Ying Lee, Guan-Chin Su, Wen-Yen Huang, Min-Yu Ko, Hsin-Yi Yeh, Geen-Dong Chang, Sung-Jan Lin, Peter Chi
Format: Article
Language:English
Published: Nature Portfolio 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08011-1