Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism

Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism

Impressive achievements in clinical trials to treat hemophilia establish a milestone in the development of gene therapy. It highlights the significance of AAV-mediated gene delivery to liver. AAV5 is a unique serotype featured by low neutralizing antibody prevalence. Nevertheless, its liver infectiv...

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Bibliographic Details
Main Authors: Yuqiu Wang, Chen Yang, Hanyang Hu, Chen Chen, Mengdi Yan, Feixiang Ling, Kathy Cheng Wang, Xintao Wang, Zhe Deng, Xinyue Zhou, Feixu Zhang, Sen Lin, Zengmin Du, Kai Zhao, Xiao Xiao
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: delivery strategies
AAV5
directed evolution
library screening
liver tropism
low seroreactivity
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312200066X

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http://www.sciencedirect.com/science/article/pii/S216225312200066X

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