Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency

Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency

Abstract Background Targetable molecular drivers of gastric cancer (GC) metastasis remain largely unidentified, leading to limited targeted therapy options for advanced GC. We aimed to identify molecular drivers for metastasis and devise corresponding therapeutic strategies. Methods We performed an...

Full description

Bibliographic Details
Main Authors: Jong-Wan Kwon, Jeong-Seop Oh, Sang Hyeok Seok, Hyeok-Won An, Yu Jin Lee, Na Yun Lee, Taehun Ha, Hyeon Ah Kim, Gyeong Min Yoon, Sung Eun Kim, Pu-Reum Oh, Su-Hyung Lee, Dominic C. Voon, Dae-Yong Kim, Jun Won Park
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Molecular Cancer
Subjects:
Cancer stem cells
CRISPR/Cas9
Wnt pathway
YAP signaling
Online Access:https://doi.org/10.1186/s12943-023-01857-0

Internet

https://doi.org/10.1186/s12943-023-01857-0

Similar Items