TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling

TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling

Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related death, with a 5-year survival of <10% and severely limited treatment options. PDAC hallmarks include profound metabolic acid production and aggressive local proliferation and invasiveness. This phenotype is supported b...

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Bibliographic Details
Main Authors: Raj R. Malinda, Katrine Zeeberg, Patricia C. Sharku, Mette Q. Ludwig, Lotte B. Pedersen, Søren T. Christensen, Stine F. Pedersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
NHE1
SLC9A1
NBCn1
SLC4A7
Merlin
proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00687/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00687/full

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