Rodent models in Down syndrome research: impact and future opportunities

Rodent models in Down syndrome research: impact and future opportunities

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse models with Down-syndrome-related features has been developed to understand this complex human chromosomal disorder. These mouse models have been important for determining genotype-phenotype relationships and ident...

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Bibliographic Details
Main Authors: Yann Herault, Jean M. Delabar, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Eugene Yu, Veronique Brault
Format: Article
Language:English
Published: The Company of Biologists 2017-10-01
Series:Disease Models & Mechanisms
Subjects:
Down syndrome
Mouse model
Chromosome engineering
Aneuploidy
Dosage-senstive gene
Online Access:http://dmm.biologists.org/content/10/10/1165

Internet

http://dmm.biologists.org/content/10/10/1165

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