Lipopolysaccharides induce a RAGE-mediated sensitization of sensory neurons and fluid hypersecretion in the upper airways

Lipopolysaccharides induce a RAGE-mediated sensitization of sensory neurons and fluid hypersecretion in the upper airways

Abstract Thoracic dorsal root ganglia (tDRG) contribute to fluid secretion in the upper airways. Inflammation potentiates DRG responses, but the mechanisms remain under investigation. The receptor for advanced glycation end-products (RAGE) underlies potentiation of DRG responses in pain pathologies;...

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Bibliographic Details
Main Authors: Manoj Nair, Santosh Jagadeeshan, George Katselis, Xiaojie Luan, Zeinab Momeni, Nicolas Henao-Romero, Paulos Chumala, Julian S. Tam, Yasuhiko Yamamoto, Juan P. Ianowski, Verónica A. Campanucci
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86069-6

Internet

https://doi.org/10.1038/s41598-021-86069-6

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