ClpC2 protects mycobacteria against a natural antibiotic targeting ClpC1-dependent protein degradation
Mycobacteria evade the toxic effects of Cyclomarin A (CymA) by massive autoupregulated expression of the partial ClpC1 homologue ClpC2 that thereby acts as a tightly binding molecular sponge to prevent CymA binding to ClpCP.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04658-9 |