Biomechanical response of ultrathin slices of hypertrophic cardiomyopathy tissue to myosin modulator mavacamten

Biomechanical response of ultrathin slices of hypertrophic cardiomyopathy tissue to myosin modulator mavacamten

Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disorder of the heart, but effective treatment options remain limited. Mavacamten, a direct myosin modulator, has been presented as novel pharmacological therapy for HCM. The aim of this study was to analyze the biomechanical...

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Bibliographic Details
Main Authors: Jorik H. Amesz, Sanne J.J. Langmuur, Lu Zhang, Olivier C. Manintveld, Arend F.L. Schinkel, Peter L. de Jong, Natasja M.S. de Groot, Yannick J.H.J. Taverne
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Living myocardial slices
Hypertrophic cardiomyopathy
Myosin modulators
Translational research
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223018346

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http://www.sciencedirect.com/science/article/pii/S0753332223018346

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