DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine learning, Mendelian randomization, eQTL and mQTL data

DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine learning, Mendelian randomization, eQTL and mQTL data

Abstract Background Intracranial aneurysms (IAs) pose a significant and intricate challenge. Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to identify potential biomarkers and therapeutic interventions. Methods We employed a comprehensive bioinformatics investiga...

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Bibliographic Details
Main Authors: Aierpati Maimaiti, Mirzat Turhon, Aimitaji Abulaiti, Yilidanna Dilixiati, Fujunhui Zhang, Aximujiang Axieer, Kaheerman Kadeer, Yisen Zhang, Aisha Maimaitili, Xinjian Yang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Translational Medicine
Subjects:
Intracranial aneurysms
DNA methylation regulator
Multi-omics
Machine learning
Genome-wide association studies
Mendelian randomization
Online Access:https://doi.org/10.1186/s12967-023-04512-w

Internet

https://doi.org/10.1186/s12967-023-04512-w

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