Glycyrrhizin arginine salt protects against cisplation-induced acute liver injury by repressing BECN1-mediated ferroptosis

Glycyrrhizin arginine salt protects against cisplation-induced acute liver injury by repressing BECN1-mediated ferroptosis

The study aimed to investigate the protective effects and biological mechanisms of glycyrrhizin arginine salt (Gly-Arg) against cisplatin (Cis)-induced liver injury. Our data showed that Gly-Arg improved Cis-induced liver injury. Further study showed that BECN1 (beclin1) and LC3-II/LC3-I protein exp...

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Bibliographic Details
Main Authors: Jun Guo, Jiameng Yin, Pu Liu, Xin Zhang, Jie Wei, Mingjun Wang, Yanxia Xiao, Yongzhan Zhen, Yajun Lin, Jian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
glycyrrhizin arginine salt
cisplatin
liver injury
BECN1-xCT complex
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1219486/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1219486/full

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