The regulations of telomerase reverse transcriptase (TERT) in cancer

Abstract Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in its promoter and phosphorylation res...

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Bibliographic Details
Main Authors: Mingdi Liu, Yuning Zhang, Yongping Jian, Liting Gu, Dan Zhang, Honglan Zhou, Yishu Wang, Zhi-Xiang Xu
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06454-7