Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children

Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children

Abstract Background The RTS,S/AS01E vaccine provides partial protection against malaria in African children, but immune responses have only been partially characterized and do not reliably predict protective efficacy. We aimed to evaluate comprehensively the immunogenicity of the vaccine at peak res...

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Main Authors: Itziar Ubillos, Aintzane Ayestaran, Augusto J Nhabomba, David Dosoo, Marta Vidal, Alfons Jiménez, Chenjerai Jairoce, Hèctor Sanz, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, Maximilian Mpina, Hermann Sorgho, Selidji Todagbe Agnandji, Simon Kariuki, Benjamin Mordmüller, Claudia Daubenberger, Kwaku Poku Asante, Seth Owusu-Agyei, Jahit Sacarlal, Pedro Aide, John J Aponte, Sheetij Dutta, Ben Gyan, Joseph J Campo, Clarissa Valim, Gemma Moncunill, Carlota Dobaño
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Medicine
Subjects:
Malaria
Vaccine
Antibody
RTS,S
Plasmodium falciparum
Immunogenicity
Online Access:http://link.springer.com/article/10.1186/s12916-018-1186-4

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http://link.springer.com/article/10.1186/s12916-018-1186-4

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