Synthesis of Novel Artemisinin, Ciprofloxacin, and Norfloxacin Hybrids with Potent Antiplasmodial Activity

Synthesis of Novel Artemisinin, Ciprofloxacin, and Norfloxacin Hybrids with Potent Antiplasmodial Activity

The synthesis and antiplasmodial evaluation of new hybrids combining the pharmacophore structures of artemisinin, ciprofloxacin or norfloxacin, and 7-chloroquinoline are reported in this study. The first step for all of the syntheses is the obtainment of key piperazine esters intermediates bearing t...

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Bibliographic Details
Main Authors: Georgia Vamvoukaki, Antonia I. Antoniou, Michel Baltas, Elisabeth Mouray, Sebastien Charneau, Philippe Grellier, Constantinos M. Athanassopoulos
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Antibiotics
Subjects:
fluoroquinolones
hybrid
conjugate
structure–activity relationship
antimalarial activity
Pf FcB1 CQ-resistant strain
Online Access:https://www.mdpi.com/2079-6382/13/2/142

Internet

https://www.mdpi.com/2079-6382/13/2/142

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