2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.

Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2'-O methyltransferase activity exhibited attenuation in primary macrophage...

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Bibliographic Details
Main Authors: Kristy J Szretter, Brian P Daniels, Hyelim Cho, Maria D Gainey, Wayne M Yokoyama, Michael Gale, Herbert W Virgin, Robyn S Klein, Ganes C Sen, Michael S Diamond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3349756?pdf=render

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http://europepmc.org/articles/PMC3349756?pdf=render

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