FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6

FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6

Abstract Background Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series of secondary injuries. We hypothesized that FGF21 may have protective effects after intracranial hemorrhage (ICH) and investigated possible underlying molecul...

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Bibliographic Details
Main Authors: Runfeng Wang, Jin Wang, Zhiguo Zhang, Bo Ma, Shukai Sun, Li Gao, Guodong Gao
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Medicine
Subjects:
FGF21
SIRT6
Endothelial cells
BBB
Mitochondria quality control
ICH
Online Access:https://doi.org/10.1186/s10020-023-00755-x

Internet

https://doi.org/10.1186/s10020-023-00755-x

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