Integrated fragmentomic profile and 5-Hydroxymethylcytosine of capture-based low-pass sequencing data enables pan-cancer detection via cfDNA

Integrated fragmentomic profile and 5-Hydroxymethylcytosine of capture-based low-pass sequencing data enables pan-cancer detection via cfDNA

Background: Using epigenetic markers and fragmentomics of cell-free DNA for cancer detection has been proven applicable. Methods: We further investigated the diagnostic potential of combining two features (epigenetic markers and fragmentomic information) of cell-free DNA for detecting various types...

Full description

Bibliographic Details
Main Authors: Zhidong Zhang, Xuenan Pi, Chang Gao, Jun Zhang, Lin Xia, Xiaoqin Yan, Xinlei Hu, Ziyue Yan, Shuxin Zhang, Ailin Wei, Yuer Guo, Jingfeng Liu, Ang Li, Xiaolong Liu, Wei Zhang, Yanhui Liu, Dan Xie
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Translational Oncology
Subjects:
Liquid biopsy
Plasma cell-free DNA
5-Hydroxymethylcytosine sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000803

Internet

http://www.sciencedirect.com/science/article/pii/S1936523323000803

Similar Items