Interaction of Cationic Carbosilane Dendrimers and Their siRNA Complexes with MCF-7 Cells Cultured in 3D Spheroids

Interaction of Cationic Carbosilane Dendrimers and Their siRNA Complexes with MCF-7 Cells Cultured in 3D Spheroids

Cationic dendrimers are effective carriers for the delivery of siRNA into cells; they can penetrate cell membranes and protect nucleic acids against RNase degradation. Two types of dendrimers (CBD-1 and CBD-2) and their complexes with pro-apoptotic siRNA (Mcl-1 and Bcl-2) were tested on MCF-7 cells...

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Bibliographic Details
Main Authors: Kamila Białkowska, Piotr Komorowski, Rafael Gomez-Ramirez, Francisco Javier de la Mata, Maria Bryszewska, Katarzyna Miłowska
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
siRNA
carbosilane dendrimers
dendriplexes
nanocarriers
3D cell culture
spheroids
Online Access:https://www.mdpi.com/2073-4409/11/10/1697

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https://www.mdpi.com/2073-4409/11/10/1697

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