Locus-Specific and Stable DNA Demethylation at the <i>H19</i>/<i>IGF2</i> ICR1 by Epigenome Editing Using a dCas9-SunTag System and the Catalytic Domain of TET1

Locus-Specific and Stable DNA Demethylation at the <i>H19</i>/<i>IGF2</i> ICR1 by Epigenome Editing Using a dCas9-SunTag System and the Catalytic Domain of TET1

DNA methylation is critically involved in the regulation of chromatin states and cell-type-specific gene expression. The exclusive expression of imprinted genes from either the maternal or the paternal allele is regulated by allele-specific DNA methylation at imprinting control regions (ICRs). Aberr...

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Bibliographic Details
Main Authors: Claudia Albrecht, Nivethika Rajaram, Julian Broche, Pavel Bashtrykov, Albert Jeltsch
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Genes
Subjects:
epigenome editing
imprinting
DNA demethylation
dCas9
SunTag
TET1
Online Access:https://www.mdpi.com/2073-4425/15/1/80

Internet

https://www.mdpi.com/2073-4425/15/1/80

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