Prediction of Amino Acid Substitutions in ABL1 Protein Leading to Tumor Drug Resistance Based on “Structure-Property” Relationship Classification Models

Prediction of Amino Acid Substitutions in ABL1 Protein Leading to Tumor Drug Resistance Based on “Structure-Property” Relationship Classification Models

Drug resistance to anticancer drugs is a serious complication in patients with cancer. Typically, drug resistance occurs due to amino acid substitutions (AAS) in drug target proteins. The study aimed at developing and validating a new approach to the creation of structure-property relationships (SPR...

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Bibliographic Details
Main Authors: Svetlana I. Zhuravleva, Anton D. Zadorozhny, Boris V. Shilov, Alexey A. Lagunin
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Life
Subjects:
sequence-structure analysis
drug resistance
molecular fragments
MNA descriptors
MultiPASS
amino acid substitution
Online Access:https://www.mdpi.com/2075-1729/13/9/1807

Internet

https://www.mdpi.com/2075-1729/13/9/1807

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