Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS Signaling Pathways

Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS Signaling Pathways

Adiponectin, an adipose-derived adipokine, possesses a hepatoprotective role in various liver disorders. It has been reported that hypoadiponectinemia can affect with the progression of non-alcoholic fatty liver diseases (NAFLD). Inflammasome activation has been recognized to play a major role durin...

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Bibliographic Details
Main Authors: Zhixia Dong, Qian Zhuang, Xin Ye, Min Ning, Shan Wu, Lungen Lu, Xinjian Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Medicine
Subjects:
adiponectin
hepatocytes
NAFLD
NLRP3 inflamamasome
AMPK
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.546445/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2020.546445/full

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