Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer

Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer

Abstract Background Chimeric antigen receptor (CAR) -T cell therapy is an efficient therapeutic strategy for specific hematologic malignancies. However, positive outcomes of this novel therapy in treating solid tumors are curtailed by the immunosuppressive tumor microenvironment (TME), wherein signa...

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Bibliographic Details
Main Authors: Jian Chen, Tianchuan Zhu, Guanmin Jiang, Qi Zeng, Zhijian Li, Xi Huang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Cancer
Subjects:
CAR-T
TREM2
PD-1
Colorectal cancer
Tumor microenvironment
Single-chain variable fragment (scFv)
Online Access:https://doi.org/10.1186/s12943-023-01830-x

Internet

https://doi.org/10.1186/s12943-023-01830-x

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