BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis

BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis

ABSTRACT Moloney murine leukemia virus (MLV) infects BALB/c mice and induces T-cell lymphoma in mice. Retroviral integration is mediated by the interaction of the MLV integrase (IN) with members of the bromodomain and extraterminal motif (BET) protein family (BRD2, BRD3, and BRD4). The introduction...

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Bibliographic Details
Main Authors: Ivan Nombela, Martine Michiels, Dominique Van Looveren, Lukas Marcelis, Sara el Ashkar, Siska Van Belle, Anne Bruggemans, Thomas Tousseyn, Jürg Schwaller, Frauke Christ, Rik Gijsbers, Jan De Rijck, Zeger Debyser
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
BALB/c mouse
BET proteins
BRD4
integrase
integration site selection
lymphomagenesis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01478-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01478-22

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