Single-cell transcriptomic atlas throughout anti-BCMA CAR-T therapy in patients with multiple myeloma

Single-cell transcriptomic atlas throughout anti-BCMA CAR-T therapy in patients with multiple myeloma

IntroductionThe emergence of chimeric antigen receptor (CAR)-T therapy targeting B cell maturation antigen (BCMA) has improved the prognosis of patients with multiple myeloma (MM); however, the majority of patients eventually experience relapse.MethodsIn this study, employing the latest single-cell...

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Bibliographic Details
Main Authors: Yuan Xia, Qian Zhao, Xuxing Shen, Yuanyuan Jin, Jing Wang, Jianfeng Zhu, Lijuan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
anti-BCMA CAR-T
multiple myeloma
scRNA-seq
resistance
endogenous T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1278749/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1278749/full

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