XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic Problems
Drug-resistant TB (DR-TB) in children is a special epidemiological, clinical, and diagnostic problem, and its global incidence remains unknown. DR-TB in children is usually of a primary nature and is most often transmitted to the child from a household contact, so these cases reflect the prevalence...
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MDPI AG
2022-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/2/438 |
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| author | Monika Kozińska Krystyna Bogucka Krzysztof Kędziora Jolanta Szpak-Szpakowska Wiesława Pędzierska-Olizarowicz Andrzej Pustkowski Ewa Augustynowicz-Kopeć |
| author_facet | Monika Kozińska Krystyna Bogucka Krzysztof Kędziora Jolanta Szpak-Szpakowska Wiesława Pędzierska-Olizarowicz Andrzej Pustkowski Ewa Augustynowicz-Kopeć |
| author_sort | Monika Kozińska |
| collection | DOAJ |
| description | Drug-resistant TB (DR-TB) in children is a special epidemiological, clinical, and diagnostic problem, and its global incidence remains unknown. DR-TB in children is usually of a primary nature and is most often transmitted to the child from a household contact, so these cases reflect the prevalence of DR-TB in the population of adult patients. The risk of infection with <i>Mycobacterium tuberculosis</i> complex (MTBC) in children depends on age, duration of exposure, proximity of contact with the infected person, and the level of source virulence. Most cases of TB in children, especially in infants, are caused by household contacts, where the main sources of infection are parents, grandparents or older siblings. However, there are many documented cases of TB transmission outside the family. The most common source of infection is an adult who is profusely positive for mycobacteria, diagnosed too late, and inadequately treated. It has been estimated that a sputum-positive patient might infect 30–50% of their household members. For this reason, active epidemiological investigation and contact tracing in the environment of sputum-positive patients are the most appropriate methods of identifying infected family members. This paper presents a case report concerning the transmission of extensively drug-resistant TB, Beijing 265 genotype, from a mother to her 10-month-old daughter. It is the first case diagnosed in Poland, and one of very few described in the literature where treatment was effective in the mother and the infant recovered spontaneously. |
| first_indexed | 2024-03-09T22:11:24Z |
| format | Article |
| id | doaj.art-793272fb7aa8498793123e455dbeb368 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T22:11:24Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-793272fb7aa8498793123e455dbeb3682023-11-23T19:32:02ZengMDPI AGDiagnostics2075-44182022-02-0112243810.3390/diagnostics12020438XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic ProblemsMonika Kozińska0Krystyna Bogucka1Krzysztof Kędziora2Jolanta Szpak-Szpakowska3Wiesława Pędzierska-Olizarowicz4Andrzej Pustkowski5Ewa Augustynowicz-Kopeć6Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Plocka 26, 01-138 Warsaw, PolandMedical Laboratory BRUSS, ALAB Group, Department of Mycobacterium Tuberculosis Diagnostics, Powstania Styczniowego 9B, 81-519 Gdynia, PolandDepartment of Tuberculosis and Lung Diseases, Specialist Hospital in Prabuty, Kuracyjna 30, 82-550 Prabuty, PolandDepartment of Tuberculosis and Lung Diseases, Specialist Hospital in Prabuty, Kuracyjna 30, 82-550 Prabuty, PolandDepartment of Allergology, Immunology and Lung Diseases, The Maciej Płażyński Polanki Children’s Hospital, Polanki 119, 80-308 Gdansk, PolandDepartment of Tuberculosis and Lung Diseases, Hospital Specialist Clinic Polanki, Polanki 119, 80-308 Gdansk, PolandDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Plocka 26, 01-138 Warsaw, PolandDrug-resistant TB (DR-TB) in children is a special epidemiological, clinical, and diagnostic problem, and its global incidence remains unknown. DR-TB in children is usually of a primary nature and is most often transmitted to the child from a household contact, so these cases reflect the prevalence of DR-TB in the population of adult patients. The risk of infection with <i>Mycobacterium tuberculosis</i> complex (MTBC) in children depends on age, duration of exposure, proximity of contact with the infected person, and the level of source virulence. Most cases of TB in children, especially in infants, are caused by household contacts, where the main sources of infection are parents, grandparents or older siblings. However, there are many documented cases of TB transmission outside the family. The most common source of infection is an adult who is profusely positive for mycobacteria, diagnosed too late, and inadequately treated. It has been estimated that a sputum-positive patient might infect 30–50% of their household members. For this reason, active epidemiological investigation and contact tracing in the environment of sputum-positive patients are the most appropriate methods of identifying infected family members. This paper presents a case report concerning the transmission of extensively drug-resistant TB, Beijing 265 genotype, from a mother to her 10-month-old daughter. It is the first case diagnosed in Poland, and one of very few described in the literature where treatment was effective in the mother and the infant recovered spontaneously.https://www.mdpi.com/2075-4418/12/2/438<i>Mycobacterium tuberculosis</i>drug resistanceXDR-tuberculosishousehold TB transmission |
| spellingShingle | Monika Kozińska Krystyna Bogucka Krzysztof Kędziora Jolanta Szpak-Szpakowska Wiesława Pędzierska-Olizarowicz Andrzej Pustkowski Ewa Augustynowicz-Kopeć XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic Problems Diagnostics <i>Mycobacterium tuberculosis</i> drug resistance XDR-tuberculosis household TB transmission |
| title | XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic Problems |
| title_full | XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic Problems |
| title_fullStr | XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic Problems |
| title_full_unstemmed | XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic Problems |
| title_short | XDR-TB Transmitted from Mother to 10-Month-Old Infant: Diagnostic and Therapeutic Problems |
| title_sort | xdr tb transmitted from mother to 10 month old infant diagnostic and therapeutic problems |
| topic | <i>Mycobacterium tuberculosis</i> drug resistance XDR-tuberculosis household TB transmission |
| url | https://www.mdpi.com/2075-4418/12/2/438 |
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