Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration

Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration

Abstract Analysis of isolated meninges and cerebrospinal fluid (CSF) of post-mortem MS cases has shown increased gene and protein expression for the pro-inflammatory cytokines: tumour necrosis factor (TNF) and interferon-γ (IFNγ). Here we tested the hypothesis that persistent production of these cyt...

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Bibliographic Details
Main Authors: Rachel E. James, Renee Schalks, Eleanor Browne, Ioanna Eleftheriadou, Carmen Picon Munoz, Nicholas D. Mazarakis, Richard Reynolds
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple sclerosis
Neurodegeneration
Demyelination
Meninges
Inflammation
Animal model
Online Access:http://link.springer.com/article/10.1186/s40478-020-00938-1

Internet

http://link.springer.com/article/10.1186/s40478-020-00938-1

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