Human inborn errors of long‐chain fatty acid oxidation show impaired inflammatory responses to TLR4‐ligand LPS

Human inborn errors of long‐chain fatty acid oxidation show impaired inflammatory responses to TLR4‐ligand LPS

Abstract Stimulation of mammalian cells with inflammatory inducers such as lipopolysaccharide (LPS) leads to alterations in activity of central cellular metabolic pathways. Interestingly, these metabolic changes seem to be important for subsequent release of pro‐inflammatory cytokines. This has beco...

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Bibliographic Details
Main Authors: Signe Mosegaard, Krishna S. Twayana, Simone W. Denis, Jeffrey Kroon, Bauke V. Schomakers, Michel vanWeeghel, Riekelt H. Houtkooper, Rikke K. J. Olsen, Christian K. Holm
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:FASEB BioAdvances
Subjects:
immunometabolism
lipopolyssacharide
long‐chain fatty acid oxidation disorders
toll‐like receptor 4
Online Access:https://doi.org/10.1096/fba.2024-00060

Internet

https://doi.org/10.1096/fba.2024-00060

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