Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse.

Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse.

Chronic stress or long-term administration of glucocorticoids disrupts the hypothalamus-pituitary-adrenal system leading to continuous high levels of glucocorticoids and insulin resistance (IR). This pre-diabetic state can eventually develop into type 2 diabetes mellitus and has been associated with...

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Bibliographic Details
Main Authors: Eva L van Donkelaar, Koen R D Vaessen, Jodi L Pawluski, Annerieke S Sierksma, Arjan Blokland, Ramón Cañete, Harry W M Steinbusch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4195581?pdf=render

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http://europepmc.org/articles/PMC4195581?pdf=render

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