Significant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs

Significant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs

Abstract Background We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2), that revealed substantially increased activity retention in the tumor. However, one major drawback of these first generation rh-b...

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Bibliographic Details
Main Authors: Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester, Thomas Günther
Format: Article
Language:English
Published: SpringerOpen 2024-03-01
Series:EJNMMI Research
Subjects:
Cholecystokinin-2 receptor (CCK-2R)
Cholecystokinin-B receptor (CCK-BR)
Medullary thyroid carcinoma (MTC)
Minigastrin
Radiohybrid
rhCCK
Online Access:https://doi.org/10.1186/s13550-024-01087-5

Internet

https://doi.org/10.1186/s13550-024-01087-5

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