Neurons undergo pathogenic metabolic reprogramming in models of familial ALS

Neurons undergo pathogenic metabolic reprogramming in models of familial ALS

Abstract Objectives: Normal cellular function requires a rate of ATP production sufficient to meet demand. In most neurodegenerative diseases (including Amyotrophic Lateral Sclerosis [ALS]), mitochondrial dysfunction is postulated raising the possibility of impaired ATP production and a need for com...

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Bibliographic Details
Main Authors: Sean-Patrick Riechers, Jelena Mojsilovic-Petrovic, Tayler B. Belton, Ram P. Chakrabarty, Mehraveh Garjani, Valentina Medvedeva, Casey Dalton, Yvette C. Wong, Navdeep S. Chandel, Gerald Dienel, Robert G. Kalb
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Metabolism
Subjects:
Glycolysis
G6PDH
Neuron
ATP
Redox
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000370

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http://www.sciencedirect.com/science/article/pii/S2212877822000370

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