Immunization with HIV-1 trimeric SOSIP.664 BG505 or founder virus C (FVCEnv) covalently complexed to two-domain CD4S60C elicits cross-clade neutralizing antibodies in New Zealand white rabbits

Immunization with HIV-1 trimeric SOSIP.664 BG505 or founder virus C (FVCEnv) covalently complexed to two-domain CD4S60C elicits cross-clade neutralizing antibodies in New Zealand white rabbits

Background: An ongoing challenge in HIV-1 vaccine research is finding a novel HIV-1 envelope glycoprotein (Env)-based immunogen that elicits broadly cross-neutralizing antibodies (bnAbs) without requiring complex sequential immunization regimens to drive the required antibody affinity maturation. Pr...

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Bibliographic Details
Main Authors: Nancy L. Tumba, Gavin R. Owen, Mark A. Killick, Maria A. Papathanasopoulos
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Vaccine: X
Subjects:
HIV-1 vaccine immunogens
Envelope glycoprotein trimers
Covalent complexes
Broadly neutralizing antibodies
New Zealand White rabbits
Immunogen design
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136222000821

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http://www.sciencedirect.com/science/article/pii/S2590136222000821

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