Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II

The convenient synthesis of a focused library (forty molecules) of novel 6,6,5-tricyclic thiazolo[5,4-f]quinazolines was realized mainly under microwave irradiation. A novel 6-aminobenzo[d]thiazole-2,7-dicarbonitrile (1) was used as a versatile molecular platform for the synthesis of various deriva...

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Bibliographic Details
Main Authors: Alicia Foucourt, Damien Hédou, Carole Dubouilh-Benard, Angélique Girard, Thierry Taverne, Anne-Sophie Casagrande, Laurent Désiré, Bertrand Leblond, Thierry Besson
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
thiazolo[5,4-f]quinazolines
kinase inhibitors
DYRK1A
DYRK1B
microwave-assisted chemistry
Dimroth rearrangement
EHT 5372
EHT 6840
EHT 1610
EHT 9851
EHT 3356
Online Access:http://www.mdpi.com/1420-3049/19/10/15411

Internet

http://www.mdpi.com/1420-3049/19/10/15411

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