Exhaustion of CD8+ central memory responder T cell differentiation provokes non-melanoma skin cancer in elderly kidney transplant recipients

Exhaustion of CD8+ central memory responder T cell differentiation provokes non-melanoma skin cancer in elderly kidney transplant recipients

IntroductionImmunosuppressive therapy prevents graft rejection but increases the risk of non-melanoma skin cancer (NMSC), especially in elderly kidney transplant recipients (KTR).MethodsIn this study, we separately investigated the differentiation of CD8+ regulatory T cells (Tregs) and responder T c...

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Bibliographic Details
Main Authors: Jonas Leonhard, Matthias Schaier, Florian Kälble, Martin Zeier, Andrea Steinborn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation
non-melanoma skin cancer
immunosuppressive therapy
CD8+ T cell differentiation
CD8+ regulatory T cells
CD8+ responder T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1164284/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1164284/full

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