Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety

Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety

Abstract Short-hairpin RNAs (shRNA), targeting knockdown of specific genes, hold enormous promise for precision-based therapeutics to treat numerous neurodegenerative disorders. However, whether shRNA constructed molecules can modify neuronal circuits underlying certain behaviors has not been explor...

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Bibliographic Details
Main Authors: Troy T. Rohn, Dean Radin, Tracy Brandmeyer, Peter G. Seidler, Barry J. Linder, Tom Lytle, John L. Mee, Fabio Macciardi
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-02879-y

Internet

https://doi.org/10.1038/s41398-024-02879-y

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