Yeast-Hydrolysate-Derived 1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic Acid Inhibits Fat Accumulation during Adipocyte Differentiation

Yeast-Hydrolysate-Derived 1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic Acid Inhibits Fat Accumulation during Adipocyte Differentiation

This study aimed to investigate the impact of yeast hydrolysate (YH) on lipogenesis, elucidate its mechanistic action, and identify the active compounds responsible for its anti-adipogenic effects. YH (2 mg/mL) significantly reduced Oil Red O-stained lipids. YH (2 mg/mL) also downregulated C/EBPβ an...

Full description

Bibliographic Details
Main Authors:	Nari Kim, Sekyung Lee, Eun-Jin Jung, Eun Young Jung, Un-Jae Chang, Cheng-Min Jin, Hyung Joo Suh, Hyeon-Son Choi
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	Foods
Subjects:	yeast hydrolysate (YH) adipogenic factor lipid synthesis SREBPs MTCA
Online Access:	https://www.mdpi.com/2304-8158/12/18/3466

Similar Items

Yeast Hydrolysate Inhibits Lipid Accumulation via Regulation of Lipid Accumulation-Related Genes in a <i>Drosophila</i> Model of High-Sugar Diet-Induced Obesity
by: Nari Kim, et al.
Published: (2023-11-01)

Combinations of Legume Protein Hydrolysates Synergistically Inhibit Biological Markers Associated with Adipogenesis
by: Cecilia Moreno, et al.
Published: (2020-11-01)

cis-(9S,10S)-Methyl 1-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate
by: Naeema Khan, et al.
Published: (2008-02-01)

The design of Hefei advanced light facility timing system
by: ZHAI Gangjia, et al.
Published: (2022-12-01)

Blue honeysuckle rich in cyanidin-3-O-glucoside inhibited adipogenic differentiation by modulation of the adipogenesis pathway in 3T3-L1 adipocytes
by: Hyun Jeong Lee, et al.
Published: (2022-10-01)

Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor
by: Xiaohui Hu, et al.
Published: (2022-09-01)

Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents
by: Ji-Wang Chern, et al.
Published: (2011-02-01)

6-Methoxy-1-(4-methoxyphenyl)-1,2,3,4-tetrahydro-9H-&#946;-carbolin-2-ium acetate
by: Mohd Mustaqim Rosli, et al.
Published: (2012-05-01)

Anti-Adipogenic Effect of Neferine in 3T3-L1 Cells and Primary White Adipocytes
by: Miey Park, et al.
Published: (2020-06-01)

Basic studies on epigenetic carcinogenesis of low-dose exposure to 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) in vitro.
by: Renjie Wang, et al.
Published: (2017-01-01)

Differential expression of sirtuin 2 and adipocyte maturation restriction: an adaptation process during hypoxia in fish
by: Padmini Ekambaram, et al.
Published: (2017-09-01)

Yeast Hydrolysate and Postmenopausal Osteoporosis
by: Yang Hee Hong, et al.
Published: (2023-02-01)

In Vitro Differentiation of Preosteoblast-Like Cells, MC3T3-E1, to Adipocytes Is Enhanced by 1,25(OH)2 Vitamin D3
by: Elisha Pendleton, et al.
Published: (2017-06-01)

mRNA expression of myogenic-adipogenic makers and adipocyte in skeletal muscle of Hanwoo calves at newborn and 6 months of age
by: Jun-Sang Ahn, et al.
Published: (2020-11-01)

(3S)-1,2,3,4-Tetrahydro-&#946;-carboline-3-carboxylic Acid from Cichorium endivia. L Induces Apoptosis of Human Colorectal Cancer HCT-8 Cells
by: Ai-Ping Wang, et al.
Published: (2012-12-01)

Mild and Efficient Winterfeldt Oxidation of 1,2,3,4-Tetrahydro-γ-carbolines for the Synthesis of Dihydropyrrolo[3,2-b]-quinolones and Pyrrolo[3,2-b]quinolones
by: Rong Sheng, et al.
Published: (2012-01-01)

Timosaponin A3 Inhibits Palmitate and Stearate through Suppression of SREBP-1 in Pancreatic Cancer
by: Yumi Kim, et al.
Published: (2022-04-01)

Mitochondrial Dysfunction Induced by N-Butyl-1-(4-Dimethylamino)Phenyl-1,2,3,4-Tetrahydro-β-Carboline-3-Carboxamide Is Required for Cell Death of Trypanosoma cruzi.
by: Hélito Volpato, et al.
Published: (2015-01-01)

INCREASED FORMATION OF PHOSPHORYLATED H2AX FOCI IN NUCLEI OF CELLS INFECTED BY HEPATITIS B AND B+D VIRUSES
by: D. S. Kostyushev, et al.
Published: (2018-08-01)

1,2,3,4-Tetrahydro-1,4-methanonaphthalene-2,3-diol
by: Jian Xu, et al.
Published: (2009-01-01)

Aza-Annulation of 1,2,3,4-Tetrahydro-β-carboline Derived Enaminones and Nitroenamines: Synthesis of Functionalized Indolizino[8,7‑b]indoles, Pyrido[1,2‑a:3,4‑b′]diindoles, Indolo[2,3‑a]quinolizidine-4-ones and Other Tetrahydro-β-carboline Fused Heterocycles
by: Anusha Avadhani, et al.
Published: (2019-10-01)

RNA-Seq and lipidomics reveal different adipogenic processes between bovine perirenal and intramuscular adipocytes
by: Xiaoyu Wang, et al.
Published: (2022-12-01)

Anti-Obesity Effects of <i>Petasites japonicus</i> (Meowi) Ethanol Extract on RAW 264.7 Macrophages and 3T3-L1 Adipocytes and Its Characterization of Polyphenolic Compounds
by: Eun Mi Ahn, et al.
Published: (2020-04-01)

CGRP Regulates the Age-Related Switch Between Osteoblast and Adipocyte Differentiation
by: Hang Li, et al.
Published: (2021-05-01)

2-(1,2,3,4-Tetrahydro-1-naphthyl)imidazolium chloride monohydrate
by: Bruno Bruni, et al.
Published: (2010-09-01)

Protective Effects of Whey Protein Hydrolysate, Treadmill Exercise, and Their Combination against Scopolamine-Induced Cognitive Deficit in Mice
by: Yeok Boo Chang, et al.
Published: (2023-12-01)

Corrigendum: CGRP Regulates the Age-Related Switch Between Osteoblast and Adipocyte Differentiation
by: Hang Li, et al.
Published: (2021-06-01)

Neuropilin 1 (NRP1) Positively Regulates Adipogenic Differentiation in C3H10T1/2 Cells
by: Yaqiong Yu, et al.
Published: (2023-04-01)

Crystal structures of main proteases of SARS-CoV-2 variants bound to a benzothiazole-based inhibitor
by: Luo Jiqing, et al.
Published: (2023-06-01)

Gut Microbiota and Bile Acids Mediate the Clinical Benefits of YH1 in Male Patients with Type 2 Diabetes Mellitus: A Pilot Observational Study
by: Yueh-Hsiang Huang, et al.
Published: (2022-09-01)

Alterations in chromatin accessibility during osteoblast and adipocyte differentiation in human mesenchymal stem cells
by: Jianyun Liu, et al.
Published: (2022-01-01)

Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study
by: Qianqian Zhai, et al.
Published: (2015-09-01)

A Pea (<i>Pisum sativum</i> L.) Seed Vicilins Hydrolysate Exhibits PPARγ Ligand Activity and Modulates Adipocyte Differentiation in a 3T3-L1 Cell Culture Model
by: Raquel Ruiz, et al.
Published: (2020-06-01)

<i>APE1/Ref-1</i> Inhibits Adipogenic Transcription Factors during Adipocyte Differentiation in 3T3-L1 Cells
by: Eun-Ok Lee, et al.
Published: (2023-02-01)

Anti-Obesity and Anti-Adipogenic Effects of Administration of Arginyl-Fructose-Enriched Jeju Barley (<i>Hordeum vulgare</i> L.) Extract in C57BL/6 Mice and in 3T3-L1 Preadipocytes Models
by: Soo-Young Lee, et al.
Published: (2022-05-01)

Hypolipidemic activity of Dracocephalum kotschyi involves FOXO1 mediated modulation of PPARγ expression in adipocytes
by: Shima Aslian, et al.
Published: (2018-10-01)

2-(1,2,3,4-Tetrahydro-9H-carbazol-1-ylidene)propanedinitrile
by: R. Velmurugan, et al.
Published: (2010-11-01)

The preparation of protein hydrolysate from defatted coconut and soybean meals /
by: 436690 Pham, Chay B., et al.

Anti-Obesity Potential of Ponciri Fructus: Effects of Extracts, Fractions and Compounds on Adipogenesis in 3T3-L1 Preadipocytes
by: Gopal Lamichhane, et al.
Published: (2022-01-01)

Mechanochemical Aza-Vinylogous Povarov Reactions for the Synthesis of Highly Functionalized 1,2,3,4-Tetrahydroquinolines and 1,2,3,4-Tetrahydro-1,5-Naphthyridines
by: José Clerigué, et al.
Published: (2021-03-01)